Natacha Bustos is a comic book artist who studied Fine Arts at the University of Granada. Her first published work was as co-author of Chernobyl-La Zona (Chernobyl-TheZone - Glénat España, 2011).

In 2015 she began working in the American market, which earned her a GLAAD award for best comic character for the series Moon Girl and Devil Dinosaur. Since then, she has created comics for Marvel, including several issues of Spider-Man Miles Morales, Runaways, Doctor Aphra and Bounty Hunters, as well as several covers and the Buffy the Vampire Slayer mini-series Willow for Boom Studios with Mariko Tamaki. She worked on the Black Panther graphic novel Into the Heartlands, and her first full comic appears in the anthology Marvel Voices: Legacy#1.

In 2021, she is part of the Stormbreakers, a program created by Marvel Comics to promote in-house artists. In 2023 she drew the Fire & Ice miniseries for DC Comics.